Endocrine Abstracts

Introduction: The anticancer action of vitamin D is currently considered one of its main properties. The main actions of vitamin D are related to the regulation of calcium levels and the normal function of the musculoskeletal system. However, its anticancer action is currently in the focus of research interests.Aim: The aim was to study the effect of vitamin D on MCF-7 human breast cancer cells in vitro.Methods: The effect...

Introduction: It has been reported that blind women with disturbed melatonin secretion have a lower incidence of breast cancer. A higher incidence of breast cancer has been reported in women in shift work, in which lower nocturnal melatonin secretion is observed. The anticancer action of melatonin is currently the focus of research interest.Aim: The aim was to study the effect of melatonin on MCF-7 breast cancer cells in vitro.<p class="abst...

Introduction: Melatonin is an indole being produced by the pineal gland and secreted mainly during the night. Melatonin is involved in the regulation of biological rhythms. The hormone possesses antioxidant action and is thought to be involved in the protection of the organism from the development of malignant tumors. Melatonin has been found to have anticancer action in vitro as is has been observed to inhibit the proliferation of cancer cells in vitro.<...

Vitamin D is a secosteroid hormone known for its skeletal effects. Recently, the extraskeletal effects of vitamin D are under investigation. Vitamin D is thought to exert an immunomodulatory effect, having multiple effects on the immune system. It is known to induce immune tolerance and also to enhance the immune response to bacteria.The aim was to study the effect of 1,25(OH)2D3 on interferon I secretion by human mononuclear cells ...

Introduction: Vitamin D is currently known for its effects on the bone and muscle systems as well as for its pleiotropic and antiproliferative effects. The relationship between vitamin D and diabetes mellitus is in the focus of scientific research. Vitamin D deficiency has been found to be associated with the development of diabetes mellitus type 1 as well as with poor glycemic control in diabetes mellitus type 2.Aim: The aim was to study the effect of v...

Introduction: Melatonin is a hormone mainly synthesized and secreted by the pineal gland. It is involved in the orchestration of circadian rhythms its levels being elevated during the hours of darkness in the human. Melatonin may have other pleiotropic functions in the human organism. In particular, it may be involved in the regulation of glucose metabolism and the pathogenesis of diabetes.Aim: The aim was to study the effect of melatonin on rat islet ce...

Introduction: Vitamin D is a hormone related to calcium homeostasis and normal function of the musculoskeletal system. Recently, the extraskeletal actions of vitamin D are the focus of scientific interest. The hormone is thought to possess anticancer properties, these properties being especially related to cancer of the prostate.Aim: The aim was to study the effect of vitamin D on PC3 prostate cancer cells in vitro.Methods...

Introduction: AGEs have been shown to be accumulated in granulosa cell layer from human ovaries in normal and in women with polycystic ovarian syndrome (PCOS) and insulin resistance. AGEs interfere with insulin signaling pathways of several target tissues and are implicated in insulin resistance mechanisms. There is evidence that within the ovary these pathways are also important for glucose metabolism and normal folliculogenesis. The effect of human glycated albumin (HGA) eit...

Introduction: Vitamin D has been found to be associated with multiple chronic diseases, including diabetes mellitus type 1 and 2, rheumatoid arthritis, systemic lupus erythematosus and other autoimmune diseases. Low vitamin D levels have also been observed in patients with obesity.Aim: The aim was to study vitamin D levels in patients with morbid obesity.Methods: In a group of 32 patients with morbid obesity, BMI 41.77±1.15 (m...

BackgroundRecent knowledge implicates a differential expression of the insulin-like growth factor-1 (IGF-1) mRNA splice variants (i.e., IGF-1Ea, IGF-1Eb and IGF-1Ec) in cancerous tissues, implying possible specific roles of the encoded IGF-1 protein isoforms in cancer biology. In particular, there is growing evidence that IGF-1Ec isoform may plays a distinct biological role in various types of cancer. The aim of the present study was to investigate wheth...